For most types of cancer, a biopsy is one of the main way to diagnose cancer. A biopsy is the removal of a small amount of tissue for examination under a microscope. Other tests can suggest that cancer is present, but only a biopsy can make a definite diagnosis. Your doctor may recommend a biopsy if something suspicious is found during a physical exam or other test. Sometimes, a biopsy may be performed with the help of an imaging test, such as an ultrasound, CT scan, or MRI. Occasionally, surgery may be needed to get a tissue sample. The type of biopsy you receive depends on where the possible tumor is located. Types of biopsy are such as fine needle aspiration, core needle, vacuum-assisted, image-guided, incisional, excisional, shave, endoscopic and bone marrow biopsys.